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Journal Article 1

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2023 1

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NAD(P)H:quinone oxidoreductase 1 1

cancer therapy 1

nanosystem 1

probe 1

target 1

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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 123-138 doi: 10.1007/s11705-022-2194-7

Abstract: The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues. NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers. Therefore, it could be a target for cancer therapy. Because it is a quinone reductase, many bioimaging probes based on quinone structures target NAD(P)H:quinone oxidoreductase 1 to diagnose tumours. Its expression is higher in tumours than in normal tissues, and using target drugs such as β-lapachone to reduce side effects in normal tissues can help. However, the physicochemical properties of β-lapachone limit its application. The problem can be solved by using nanosystems to deliver β-lapachone. This mini-review summarizes quinone-based fluorescent, near-infrared and two-photon fluorescent probes, as well as nanosystems for delivering the NAD(P)H:quinone oxidoreductase 1-activating drug β-lapachone. This review provides valuable information for the future development of probes and nano-delivery systems that target NAD(P)H:quinone oxidoreductase 1.

Keywords： NAD(P)H:quinone oxidoreductase 1     cancer therapy     target     probe     nanosystem    

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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Journal Article